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Sunday, August 9, 2020 | History

1 edition of Mutagenicity and carcinogenicity assessment of 1,3-butadiene found in the catalog.

Mutagenicity and carcinogenicity assessment of 1,3-butadiene

Mutagenicity and carcinogenicity assessment of 1,3-butadiene

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  • 28 Currently reading

Published by Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency in Washington, D.C .
Written in English

    Subjects:
  • Butadiene -- Toxicology,
  • Carcinogens,
  • Mutagens,
  • Environmental health

  • Edition Notes

    ContributionsUnited States. Environmental Protection Agency. Office of Health and Environmental Assessment
    The Physical Object
    Pagination1 v. (various pagings) :
    ID Numbers
    Open LibraryOL14274065M

    The International Chemical Safety Card (ICSC ) for 1,3- butadiene, produced by the International Programme on Chemical Safety (IPCS, ), has also been reproduced in this document. 1,3-Butadiene (CAS No. ) is a product of incomplete combustion resulting from natural processes and human activity. It is also an industrial chemical. carcinogenicity of this chemical was announced in the. California Regulatory Notice Register. on August 6, This document reviews the available scientific evidence on the carcinogenic potential of 1,3-hexachlorobutadiene. It was released as the draft document. Evidence on the Carcinogenicity of 1,3-Hexachlorobutadiene. in August

    Abelson's editorial contains an unbalanced and cursory review of 1,3-butadiene toxicity and of the recent National Institute for Occupational Safety and Health (NIOSH) risk assessment of butadiene. A thorough review of the metabolic, toxicologic, and epidemiologic data for butadiene is available. The NIOSH risk assessment was based on a recent National Toxicology Program study, in which B6C3F1 mic. 1, 3-Butadiene (BD) is a carcinogen in both rats and mice with mice being substantially more sensitive than rats. It is not known if BD poses a carci We use cookies to enhance your experience on our continuing to use our website, you are agreeing to our use of cookies.

    Furan is a heterocyclic organic compound, consisting of a five-membered aromatic ring with four carbon atoms and one oxygen. Chemical compounds containing such rings are also referred to as furans. Furan is a colorless, flammable, highly volatile liquid with a boiling point close to room temperature. It is soluble in common organic solvents, including alcohol, ether, and acetone, and is.   1,3-Butadiene is a chemical made from the processing of petroleum. It is the 36th highest volume chemical produced in the United States. It is a colorless gas with a mild gasoline-like odor. About 75% of the manufactured 1,3-butadiene is used to make synthetic rubber. Synthetic rubber is widely used for tires on cars and trucks. 1,3-Butadiene is also used to make plastics including acrylics.


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Mutagenicity and carcinogenicity assessment of 1,3-butadiene Download PDF EPUB FB2

PREFACE The Mutagenicity and Carcinogenicity Assessment of 1,3-Butadiene was prepared to serve as a source document for Agency-wide use. This document was developed primarily for use by the U.S.

Environmental Protection Agency's (EPA) Office of Air Quality Planning and Standards (OAQPS) to support decision-making regarding possible designation of 1,3-butadiene as a hazardous air pollutant.

Get this from a library. Mutagenicity and carcinogenicity assessment of 1,3-butadiene. [United States. Environmental Protection Agency. Office of Health and Environmental Assessment.;]. Ott MG. Assessment of 1,3-butadiene epidemiology studies.

Environ Health Perspect. Jun; – [PMC free article] Goodrow T, Reynolds S, Maronpot R, Anderson M. Activation of K-ras by codon 13 mutations in C57BL/6 X C3H F1 mouse tumors induced by exposure to 1,3-butadiene.

Cancer Res. Aug 1; 50 (15)–Cited by: United States. Environmental Protection Agency. Office of Health and Environmental Assessment. Mutagenicity and carcinogenicity assessment of 1,3-butadiene [microform] Office of Health and Environmental Assessment, Office of Research and Development, U.S.

Environmental Protection Agency Washington, D.C. Wikipedia Citation. 1,3-Butadiene (BD) is an air pollutant and a known carcinogen. 1,2,3,4-Diepoxybutane (DEB), one of the major in vivo metabolites of BD, is considered the ultimate culprit of BD mutagenicity.

A quantitative assessment of the risk of cancer associated with exposure to 1,3-butadiene, based on a low dose inhalation study in B6C3F1 mice. National Institute for Occupational Safety and Health (NIOSH) (a). Submitted to the Occupational Safety and Health Administration (OSHA) for.

1,3-Butadiene is a colorless gas with a mild gasoline-like odor. (1) The odor threshold for 1,3-butadiene is parts per million (ppm). (7) The chemical formula for 1,3-butadiene is C 4 H 6, and the molecular weight is g/mol.

(1) The vapor pressure for 1,3-butadiene is mm Hg at 25 °C, and it has an octanol/water partition. This assessment was conducted to review the new information that has become available since EPA’s health assessment of 1,3-butadiene.

1,3-Butadiene is a gas used commercially in the production of styrene-butadiene rubber, plastics, and thermoplastic resins. The major environmental source of. 1,3-Butadiene (BD), a widely used industrial chemical and a ubiquitous environmental pollutant, is a known human carcinogen.

Although genotoxicity is an established mechanism of the tumorigenicity. Sep MUTAGENICITY AND CARCINOGENICITY ASSESSMENT OF 1,3-BUTADIENE (Report) Feb MUTAGENICITY AND CARCINOGENICITY ASSESSMENT OF 1,3-BUTADIENE.

REVIEW DRAFT (Report) Dec Health And Environmental Effects Profile for 2. Mutagenicity of 1,3-butadiene at the hprt locus of T-lymphocytes following inhalation exposures of female mice and rats. Mutat Res (). () Sisk SC, Pluta LJ, Bond JA, Recio L.

Molecular analysis of lacl mutants from bone marrow of B6C3F1 transgenic mice following inhalation exposure to 1,3-butadiene. 1,3-Butadiene CAS No. Known to be a human carcinogen First listed in the Fifth Annual Report on Carcinogens () H2C C H H C CH2 Carcinogenicity 1,3-Butadiene is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans, including epide-miological and mechanistic studies.

1,3-Butadiene was. ABSTRACT This assessment was conducted to review the new information that has become available since EPA's health assessment of 1,3-butadiene.

1,3-Butadiene is a gas used commercially in the production of styrene-butadiene rubber, plastics, and thermoplastic resins. Abstract. 1,3-Butadiene (CAS No. ) is a colorless, flammable, noncorrosive gas (boiling point: —°C; vapour pressure at 20°C: mmHg) produced largely as a coproduct of ethylene production (Kirshenbaum ).

Abstract. 1,3-Butadiene, CH 2 =CH—CH=CH 2 (CAS No. ), is a colorless, noncorrosive gas having a boiling point of — °C and a vapor pressure of 1, mm Hg at 20°C (Kirshenbaum ). 1,3-Butadiene is a highly reactive material that can form the dimer, 4-vinyl-cyclohexene, and is flammable at atmospheric concentrations of 2% or higher.

1,3-Butadiene can form explosive peroxides. 1,3-Butadiene is an alkene with the chemical formula C 4 H 6 [19,]. It is insoluble in water, and exists as a colorless gas at room temperature with a gasoline-like odor [19,].

1,3-Butadiene has been emitted as an industry-related air pollutant in the United States since the s as a by-product of ethylene manufacture [19,].

Part I: Carcinogenicity of 1,2,3,4-Diepoxybutane Rogene F Henderson, Edward B Barr, Steven A Belinsky, Janet M Benson, Fletcher F Hahn, and Margaret Ménache. Part II: Roles of Two Metabolites of 1,3-Butadiene in Mediating Its in Vivo Genotoxicity Leslie Recio, Christopher J Saranko, and Ann-Marie Steen.

Part III: In Vivo Mutation of the Endogenous hprt Genes of Mice and Rats by 1,3-Butadiene. Abstract. This paper discusses the Environmental Protection Agency's (EPA) risk assessment of 1,3-butadiene.

The assessment focuses on estimation of increased cancer risk to populations living near industrial sources of 1,3-butadiene emissions rather than occupationally exposed populations.

Sloane K. Tilley, Rebecca C. Fry, in Systems Biology in Toxicology and Environmental Health, 1,3-Butadiene: Background. 1,3-Butadiene is an alkene with the chemical formula C 4 H 6 [19,].It is insoluble in water, and exists as a colorless gas at room temperature with a gasoline-like odor [19,].

1,3-Butadiene has been emitted as an industry-related air pollutant in the. A hour Median Tolerance Limit(LC 50) of mg/L for pinfish (Lagodon rhomboides) is frequently quoted for butadiene, but the actual chemical tested was cyano-1,3-butadiene (Daugherty and Garrett, ), and so the result is not relevant to this assessment.

Predicted acute and chronic toxicity values for freshwater fish are presented in. 1,3-Butadiene is a synthetic, colorless gas that is practically insoluble in water and soluble in ethanol, ether, acetone and is used primarily as a monomer to manufacture many different types of polymers and copolymers and as a chemical intermediate in the production of industrial chemicals.1,3-Butadiene is often referred to simply as butadiene.

However, the general term butadiene includes both the common industrial chemical 1,3-butadiene and 1,2-butadiene, a contaminant in some industrial processes.

Physical characteristics of 1,3-butadiene are shown below.Learn about 1,3-butadiene, exposure to which can raise your risk of leukemia. 1,3-Butadiene is a gas used to produce synthetic rubber products, such as tires, resins, and plastics.

Other sources of exposure include car exhaust; tobacco smoke; and polluted air and water near industrial facilities.